Thin film voltammetry of metabolic enzymes in rat liver microsomes

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Quinol-based metabolic cycle for estrogens in rat liver microsomes.

According to a recently reported metabolic pathway, phenolic A-ring estrogens are metabolized in rat liver microsomes partially to the corresponding quinols by cytochrome P450 isoenzymes. We found that these quinols could, in turn, undergo reduction to regenerate the parent estrogens consumed during the metabolic process. Among the tested endogenous reducing agents, NADH and especially NADPH pr...

متن کامل

Metabolic activation and DNA adduct formation of Benzo(a) pyrene by adult and newborn rat skin and liver microsomes

Benzo(a) pyrene is a carcinigen polycyclic aromatic hydrocarbon which diffuses into the environment from combustion of organic meterials.based on various epidemiological evidences it is related to lung,skin and liver cancer.mutagenicity,and immunosuppressivety are among important biological effects of Benzo(a) pyrene.after absorbtion and distribution in the body,it undergoes epoxidation by cyto...

متن کامل

New metabolic pathways for flavanones catalyzed by rat liver microsomes.

Flavonoids represent a diverse group of natural pigments widely distributed in the plant kingdom and are an important component of human diet due to their high content in fruits and vegetables. Since many flavonoids have been shown to be potent inhibitors, substrates, and even inducers of various cytochrome P450 isoforms, there is considerable interest in studying interactions of this class of ...

متن کامل

Rat-liver Mitochondria and Microsomes

Work by Marinetti, Erbland & Stotz (1958) on pig-heart-cell fractions and by Macfarlane, Gray & Wheeldon (1960) on rat-liver-cell fractions have indicated that the mitochondrial and microsomal phospholipids may differ significantly in composition. In view of the results obtained by Collins (1960) and by Collins & Shotlander (1961), showing the widespread occurrence of complex amino-phospholipid...

متن کامل

Dihydralazine-induced inactivation of cytochrome P450 enzymes in rat liver microsomes.

Dihydralazine is known to induce immunoallergic hepatitis, and the anti-liver microsome (anti-LM) autoantibodies found in the serum of the patients have been reported to react with cytochrome P450 1A2 (CYP1A2). It is thus suggested that a reactive metabolite of dihydralazine covalently binds to the P450 protein and triggers an immunological response as a neoantigen. We investigated the selectiv...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Electrochemistry Communications

سال: 2007

ISSN: 1388-2481

DOI: 10.1016/j.elecom.2007.07.002